The life cycle of non-polio enteroviruses and how to target it
J Baggen, HJ Thibaut, JRPM Strating… - Nature Reviews …, 2018 - nature.com
The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus,
coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse …
coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse …
[HTML][HTML] Enterovirus A71 antivirals: past, present, and future
Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
Antivirals and vaccines for Enterovirus A71
JY Lin, YA Kung, SR Shih - Journal of biomedical science, 2019 - Springer
Abstract Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children
under five years old. EV-A71 infection in infants or young children can cause hand-foot-and …
under five years old. EV-A71 infection in infants or young children can cause hand-foot-and …
Enterovirus A71 proteins: structure and function
J Yuan, L Shen, J Wu, X Zou, J Gu, J Chen… - Frontiers in …, 2018 - frontiersin.org
Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public
health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and …
health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and …
[HTML][HTML] Direct-acting antivirals and host-targeting strategies to combat enterovirus infections
L Bauer, H Lyoo, HM van der Schaar… - Current opinion in …, 2017 - Elsevier
Highlights•Enteroviruses cause many human diseases, yet no antiviral drugs are
available.•Capsids and viral enzymes are promising targets for direct-acting antiviral …
available.•Capsids and viral enzymes are promising targets for direct-acting antiviral …
[HTML][HTML] Advances in anti-EV-A71 drug development research
Abstract Background Enterovirus A71 (EV-A71) is capable of causing hand, foot and mouth
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …
The compromise of virtual screening and its impact on drug discovery
O Slater, M Kontoyianni - Expert opinion on drug discovery, 2019 - Taylor & Francis
Introduction: Docking and structure-based virtual screening (VS) have been standard
approaches in structure-based design for over two decades. However, our understanding of …
approaches in structure-based design for over two decades. However, our understanding of …
Enterovirus D68 antivirals: past, present, and future
Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in
children. In severe cases, it can lead to neurological complications such as acute flaccid …
children. In severe cases, it can lead to neurological complications such as acute flaccid …
The function and mechanism of enterovirus 71 (EV71) 3C protease
W Wen, Z Qi, J Wang - Current Microbiology, 2020 - Springer
Abstract Enterovirus 71 (EV71) is the main pathogen of the hand, foot, and mouth disease. It
was firstly isolated from sputum specimens of infants with central nervous system diseases …
was firstly isolated from sputum specimens of infants with central nervous system diseases …
Design, synthesis, biological evaluation, and molecular dynamics simulation of influenza polymerase PB2 inhibitors
X Li, Y Xu, W Li, J Che, X Zhao, R Cao, X Li, S Li - Molecules, 2023 - mdpi.com
The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been
identified as a promising target for the treatment of influenza. To expand the chemical space …
identified as a promising target for the treatment of influenza. To expand the chemical space …