In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …

The current available therapeutics face several challenges such as the development of ideal
drug delivery systems towards the goal of personalized treatments for patients benefit. The …

In multicellular organisms, expression profiling in spatially defined regions is crucial to
elucidate cell interactions and functions. Here, we establish a transcriptome profiling method …

AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides | Journal of the American
Chemical Society ACS ACS Publications C&EN CAS Find my institution Log In Journal of the …

Caged siRNAs with a single photolabile linker and/or vitamin E (vitE) modification at the 5′
terminal were rationally designed and synthesized. These virtually inactive caged siRNAs …

A novel photocaged PI3K inhibitor 2 was designed and synthesized by introducing a
cascade photocaging group to block its key interaction with the kinase. Upon UV light …

Detection of specific mRNA in living cells has attracted significant attention in the past
decade. Probes that can be easily delivered into cells and activated at the desired time can …

Circular non-coding RNAs are found to play important roles in biology but are still relatively
unexplored as a structural motif for chemically regulating gene function. Here, we …

Herein, we report a series of di-anionic supramolecular self-associating amphiphiles (SSAs).
We elucidate the antimicrobial properties of these SSAs against both methicillin resistant …

Expression profiling in spatially defined regions is crucial for systematically understanding
tissue complexity. Here, we report a method of photo-irradiation for in-situ barcoding …