Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

This account of the mechanisms of scleroderma highlights the genetic and molecular
changes that cause the vascular changes and fibrosis in the disease. The role of …

A unique feature of systemic sclerosis (SSc) that distinguishes it from other fibrotic disorders
is that autoimmunity and vasculopathy characteristically precede fibrosis. Moreover, fibrosis …

Systemic sclerosis (SSc), also known as scleroderma, is a rare connective tissue disease
characterized by vascular and immune dysfunction, leading to fibrosis that can damage …

Background Scleroderma is a clinically heterogeneous disease with a complex phenotype.
The disease is characterized by vascular dysfunction, tissue fibrosis, internal organ …

Early diagnosis of cutaneous T cell lymphoma (CTCL) is difficult and takes on average 6
years after presentation, in part because the clinical appearance and histopathology of …

Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for
gastric cancer. This pathogen has also been considered a potential trigger of gastric …

Scleroderma [also known as systemic sclerosis (SSc)] is a complex autoimmune disease
characterised by pathological remodelling of connective tissues. Although the earliest and …

This review discusses the clinical and physiologic principles of systemic sclerosis, a disease
of unknown origin characterized by excessive deposition of collagen and other connective …