Humans express at least two distinct β-glucuronidase enzymes that are involved in disease:
exo-acting β-glucuronidase (GUSB), whose deficiency gives rise to mucopolysaccharidosis …

Plant polysaccharides represent a virtually unlimited feedstock for the generation of biofuels
and other commodities. However, the extraordinary recalcitrance of plant polysaccharides …

The retaining endo-β-D-glucuronidase Heparanase (HPSE) is the primary mammalian
enzyme responsible for breakdown of the glycosaminoglycan heparan sulfate (HS). HPSE …

Cyclophellitol and cyclophellitol‐aziridine are potent, mechanism‐based and irreversible
retaining β‐glucosidase inhibitors. We have become interested in these configurational β …

The construction of large, phylogenetically diverse libraries of synthetic genes from a
sequence-based family allows rapid evaluation of the substrate specificity encoded within …

Glucokinase phosphorylated a series of C-1 fluorinated α-d-gluco-heptuloses. These
phosphorylated products were discovered to be inhibitors of α-phosphomannomutase …

Small molecule irreversible inhibitors are valuable tools for determining catalytically
important active-site residues and revealing key details of the specificity, structure, and …

Constructed wetland-microbial fuel cells are used to treat heavy metal and/or refractory
organic wastewater. However, the electron transport mechanism of downflow Leersia …

Oxocarbenium ions play a pivotal role in the chemistry and biochemistry of glycosides. In
this thesis I prepared carbocyclic glycoside analogs that can generate allylic cations in the …

Humans express at least two distinct β-glucuronidase enzymes involved in disease: exo-
acting β-17 glucuronidase (GUSB), whose deficiency gives rise to mucopolysaccharidosis …