Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

Inherited mitochondrial DNA (mtDNA) diseases were discovered 30 years ago, and their
characterization has provided a new perspective on the etiology of the common metabolic …

The unorthodox genetics of the mtDNA is providing new perspectives on the etiology of the
common “complex” diseases. The maternally inherited mtDNA codes for essential energy …

Maternally inherited mitochondrial (mt) DNA mutations can cause fatal or severely
debilitating syndromes in children,,, with disease severity dependent on the specific gene …

Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a
broad range of debilitating and fatal diseases. Reproductive technologies designed to …

Mitochondrial diseases are among the most common and most complex of all inherited
genetic diseases. The involvement of both the mitochondrial and nuclear genome presents …