Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress

ER Christoforou, AN Sferruzzi-Perri - Cellular and Molecular Life Sciences, 2020 - Springer
The results of different human epidemiological datasets provided the impetus to introduce
the now commonly accepted theory coined as 'developmental programming', whereby the …

Importance of the lactation period in developmental programming in rodents

GL Rodríguez-González, CJ Bautista… - Nutrition …, 2020 - academic.oup.com
Lactation is a critical period during which maternal nutritional and environmental challenges
affect milk composition and, therefore, organ differentiation, structure, and function in …

The impact of a maternal and offspring obesogenic diet on daughter's oocyte mitochondrial ultrastructure and bioenergetic responses. Insights from an outbred mouse …

I Xhonneux, WFA Marei, B Meulders, S Andries… - Frontiers in …, 2023 - frontiersin.org
Obesity affects oocyte mitochondrial functions and reduces oocyte quality and fertility.
Obesity may also increase the risk of metabolic disorders in the offspring. Children are likely …

[PDF][PDF] Histological studies of the heart and biochemical changes due to the perinatal consumption of Hibiscus sabdariffa (flavonoid-rich extract) to feed-restricted rats …

OO Chukwu, CU Emelike, NG Konyefom, SN Ibekailo… - 2023 - journals.ut.ac.ir
Background: Experiments using animal models have indicated that maternal diet during the
perinatal period can drastically impact the life-long susceptibility of offspring to chronic …

Nutrient evaluation of the seed, pulp, flesh, and peel of spaghetti squash

Y Li, HS RAMASWAMY, J Li, Y Gao, C Yang… - Food Science and …, 2021 - SciELO Brasil
The objective of this study was to evaluate the chemical composition of the seed, pulp, flesh,
and peel of spaghetti squash (SS) in order to assess its nutritional and health benefits …

Longitudinal effects of growth restriction on the murine gut microbiome and metabolome

MA Quinn, AE Pritchard, JR Visker… - American Journal …, 2022 - journals.physiology.org
Undernutrition-induced growth restriction in the early stages of life increases the risk of
chronic disease in adulthood. Although metabolic impairments have been observed, few …

Overfeeding during lactation in rats is associated with cardiovascular insulin resistance in the short-term

D González-Hedström, L Guerra-Menéndez… - Nutrients, 2020 - mdpi.com
Childhood obesity is associated with metabolic and cardiovascular comorbidities. The
development of these alterations may have its origin in early life stages such as the lactation …

Rodent models of metabolic disorders: considerations for use in studies of neonatal programming

KG Ibrahim, D Usman, MB Bello, I Malami… - British Journal of …, 2022 - cambridge.org
Epidemiologically, metabolic disorders have garnered much attention, perhaps due to the
predominance of obesity. The early postnatal life represents a critical period for …

[HTML][HTML] Adipocytes Are the Only Site of Glutamine Synthetase Expression Within the Lactating Mouse Mammary Gland

H Le, M Nguyen, HECCC Manso, MD Wang… - Current Developments …, 2024 - Elsevier
Background Glutamine in milk is believed to play an important role in neonatal intestinal
maturation and immune function. For lactating mothers, glutamine utilization is increased to …

Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats

N Muhammad, BW Lembede… - Journal of Developmental …, 2021 - cambridge.org
During the early postnatal period, dietary manipulations can alter the developmental
trajectory of the growing offspring, causing beneficial or adverse health outcomes later in …