Highlights•Novel devices are posing challenges to existing spike sorting pipelines.•Spike
sorting methodology is expanding to handle thousands to millions of neurons.•Multi-stage …

Modeling and simulation in computational neuroscience is currently a research enterprise to
better understand neural systems. It is not yet directly applicable to the problems of patients …

Biophysical modeling of neuronal networks helps to integrate and interpret rapidly growing
and disparate experimental datasets at multiple scales. The NetPyNE tool (www. netpyne …

State-of-the-art software tools for neuronal network simulations scale to the largest
computing systems available today and enable investigations of large-scale networks of up …

The need for reproducible, credible, multiscale biological modeling has led to the
development of standardized simulation platforms, such as the widely-used NEURON …

The purpose of this study is to develop a primary motor cortex (M1)-basal ganglia–thalamus
model capable of reproducing the physiological phenomenon of exaggerated phase …

We developed a detailed model of macaque auditory thalamocortical circuits, including
primary auditory cortex (A1), medial geniculate body (MGB), and thalamic reticular nucleus …

The primary somatosensory cortex (S1) of mammals is critically important in the perception
of touch and related sensorimotor behaviors. In 2015, the Blue Brain Project (BBP) …

The primary motor cortex (M1) contains interconnected and diverse layers that play an
important role in motor execution. In recent years, M1 has emerged as one of the hot targets …

Understanding cortical function requires studying multiple scales: molecular, cellular, circuit,
and behavioral. We develop a multiscale, biophysically detailed model of mouse primary …