Microfluidics for nano-drug delivery systems: From fundamentals to industrialization

H Zhang, J Yang, R Sun, S Han, Z Yang… - Acta Pharmaceutica Sinica …, 2023 - Elsevier
In recent years, owing to the miniaturization of the fluidic environment, microfluidic
technology offers unique opportunities for the implementation of nano drug delivery systems …

Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs

J Xin, M Qin, G Ye, H Gong, M Li, X Sui… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Self-emulsifying drug delivery systems (SEDDS) are formulations consisting of
oil phase, emulsifiers, and co-emulsifiers, which can be spontaneously emulsified in the …

[HTML][HTML] Counterion optimization for hydrophobic ion pairing (HIP): unraveling the key factors

V Claus, M Sandmeier, N Hock, H Spleis… - International Journal of …, 2023 - Elsevier
In the present study, various surfactants were combined with insulin (INS), bovine serum
albumin (BSA) and horseradish peroxidase (HRP) via hydrophobic ion pairing to increase …

Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment

HMK Ebada, MMA Nasra, RA Nassra, OY Abdallah - Drug Delivery, 2022 - Taylor & Francis
Novel intra-articular nanoreservoirs were implemented employing different cartilage
targeting approaches to improve cartilage bioavailability of a chondroprotective drug, cassic …

Vitamin D3-Loaded Nanoemulsions as a Potential Drug Delivery System for Autistic Children: Formulation Development, Safety, and Pharmacokinetic Studies

MH Asfour, SH Abd El-Alim, AA Kassem, A Salama… - AAPS …, 2023 - Springer
The aim of the current study is the development of a vitamin D3 (VD3)-loaded nanoemulsion
(NE) formulation to improve VD3 oral bioavailability for management of vitamin D …

Vilazodone-phospholipid mixed micelles for enhancing oral bioavailability and reducing pharmacokinetic variability between fed and fasted states

HS El Said, A Lalatsa, AM Al-Mahallawi… - International Journal of …, 2022 - Elsevier
Despite the effectiveness and high tolerability of vilazodone (VLZ) as an antidepressant, its
use is still limited due to its poor solubility and food dependent absorption. This study aims to …

Quality by Design-Based Development of Solid Self-Emulsifying Drug Delivery System (SEDDS) as a Potential Carrier for Oral Delivery of Lysozyme

M Šahinović, A Hassan, K Kristó, G Regdon Jr… - Pharmaceutics, 2023 - mdpi.com
For many years, researchers have been making efforts to find a manufacturing technique, as
well as a drug delivery system, that will allow for oral delivery of biopharmaceuticals to their …

Preparation of 2-methoxyestradiol self-emulsified drug delivery system and the effect on combination therapy with doxorubicin against MCF-7/ADM cells

C Yu, C Li, H Pan, T Li, S He - AAPS PharmSciTech, 2022 - Springer
Due to the poor solubility and bioavailability of 2-methoxyestradiol (2-ME), 2-ME emulsified
drug delivery system (2-ME-SEDDS) was designed and characterized. After dilution with 5 …

Immunoregulatory role of hesperidin against ovalbumin (OVA)-induced bronchial asthma and depression in rats

A Salama, MSO Gouida, NN Yassen… - … Archives of Pharmacology, 2023 - Springer
Links between bronchial asthma and depression have recently become a great subject of
interest. The present study was carried out to assess the protective role of hesperidin against …

[HTML][HTML] Oral lipid nanocomplex of BRD4 PROteolysis TArgeting Chimera and vemurafenib for drug-resistant malignant melanoma

A Saraswat, R Vartak, R Hegazy, Y Fu, TJR Rao… - Biomedicine & …, 2023 - Elsevier
BRAF inhibitors (BRAFi) like vemurafenib (VEM) provide initial regression in mutated
melanoma but rapidly develop resistance. Molecular pathways responsible for development …