Considering bias and conflicts of interest among the included studies
I Boutron, MJ Page, JPT Higgins… - … systematic reviews of …, 2019 - Wiley Online Library
Bias can arise because of the actions of primary study investigators or because of the
actions of review authors, or may be unavoidable due to constraints on how research can be …
actions of review authors, or may be unavoidable due to constraints on how research can be …
Industry sponsorship and research outcome
Background Clinical research affecting how doctors practice medicine is increasingly
sponsored by companies that make drugs and medical devices. Previous systematic …
sponsored by companies that make drugs and medical devices. Previous systematic …
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …
trials. However, the completeness of trial protocols is often inadequate. To help improve the …
Reducing waste from incomplete or unusable reports of biomedical research
Research publication can both communicate and miscommunicate. Unless research is
adequately reported, the time and resources invested in the conduct of research is wasted …
adequately reported, the time and resources invested in the conduct of research is wasted …
Failure of investigational drugs in late-stage clinical development and publication of trial results
TJ Hwang, D Carpenter, JC Lauffenburger… - JAMA internal …, 2016 - jamanetwork.com
Importance Many investigational drugs fail in late-stage clinical development. A better
understanding of why investigational drugs fail can inform clinical practice, regulatory …
understanding of why investigational drugs fail can inform clinical practice, regulatory …
Increasing value and reducing waste: addressing inaccessible research
The methods and results of health research are documented in study protocols, full study
reports (detailing all analyses), journal reports, and participant-level datasets. However …
reports (detailing all analyses), journal reports, and participant-level datasets. However …
[图书][B] Deadly medicines and organised crime: how big pharma has corrupted healthcare
P Gotzsche - 2019 - taylorfrancis.com
PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART
DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the …
DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the …
GRADE guidelines: 5. Rating the quality of evidence—publication bias
In the GRADE approach, randomized trials start as high-quality evidence and observational
studies as low-quality evidence, but both can be rated down if a body of evidence is …
studies as low-quality evidence, but both can be rated down if a body of evidence is …
[HTML][HTML] Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials
Background Valid assessment of drug efficacy and safety requires an evidence base free of
reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval …
reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval …
Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes
I Boutron, S Dutton, P Ravaud, DG Altman - Jama, 2010 - jamanetwork.com
Context Previous studies indicate that the interpretation of trial results can be distorted by
authors of published reports. Objective To identify the nature and frequency of distorted …
authors of published reports. Objective To identify the nature and frequency of distorted …