The defining hallmark of stem cells is their ability to self-renew and maintain multipotency.
This capacity depends on the balance of complex signals in their microenvironment. Low …

Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …

Chromosomal architecture is known to influence gene expression, yet its role in controlling
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …

Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …

During cellular reprogramming, only a small fraction of cells become induced pluripotent
stem cells (iPSCs). Previous analyses of gene expression during reprogramming were …

Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell
populations through ectopic expression of defined factors. It remains unclear whether iPSCs …

The epigenomes of early mammalian embryos are extensively reprogrammed to acquire a
totipotent developmental potential. A major initial event in this reprogramming is the active …

During development, cells start in a pluripotent state, from which they can differentiate into
many cell types, and progressively develop a narrower potential. Their gene-expression …

Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic
expression of defined transcription factors has raised fundamental questions regarding the …

The developmental programme of embryogenesis is controlled by both genetic and
epigenetic mechanisms. An emerging theme from recent studies is that the regulation of …