Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …

Bis‐heterocycles (BHCs) are hybrid molecules comprising two linked, bound, spacer, or
fused heterocyclic skeletons. In recent years, these compounds have attracted increased …

Tetrazole is a most versatile pharmacophore of which more than twenty FDAapproved drugs
have been marketed globally for the management of various diseases. In spite of many …

The synthesis of novel 3-tetrazolylmethyl-4H-chromen-4-ones via an Ugi-azide
multicomponent reaction and their biological evaluation against Entamoeba histolytica …

Lactams are very important heterocycles as a result of their presence in a wide range of
bioactive molecules, natural products and drugs, and also due their utility as versatile …

The aldol reaction has been evaluated in combination with the Ugi multicomponent reaction
to assemble richly decorated mono-and polycyclic systems via expeditious cascade …

1, 5-Disubstituted tetrazoles are an important drug-like scaffold known for their ability to
mimic the cis-amide bond conformation. The scaffold is readily accessible via substitution of …

The Pomeranz–Fritsch reaction and its Schlittler–Müller modification were successfully
applied in the Ugi postcyclization strategy by using orthogonally protected …

The synthesis of all 20 common natural proteinogenic and 4 otherα‐amino acid‐isosteric α‐
amino tetrazoles has been accomplished, whereby the carboxyl group is replaced by the …