Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer

R Sarkar, Z Xu, CJ Perera, MV Apte - Seminars in cancer biology, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that is
characterised by a prominent collagenous stromal reaction/desmoplasia surrounding …

Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment

L Wang, Y Liu, Y Dai, X Tang, T Yin, C Wang, T Wang… - Gut, 2023 - gut.bmj.com
Objective Innate immunity plays important roles in pancreatic ductal adenocarcinoma
(PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune …

Immunomodulatory role of neuropeptides in the cornea

S Puri, BM Kenyon, P Hamrah - Biomedicines, 2022 - mdpi.com
The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …

The North American Neuroendocrine Tumor Society consensus guidelines for surveillance and management of metastatic and/or unresectable pheochromocytoma …

L Fishbein, J Del Rivero, T Else, JR Howe, SL Asa… - Pancreas, 2021 - journals.lww.com
This manuscript is the result of the North American Neuroendocrine Tumor Society
consensus conference on the medical management and surveillance of metastatic and …

Nucleic acid cancer vaccines targeting tumor related angiogenesis. Could mRNA vaccines constitute a game changer?

S Tadic, A Martínez - Frontiers in Immunology, 2024 - frontiersin.org
Tumor related angiogenesis is an attractive target in cancer therapeutic research due to its
crucial role in tumor growth, invasion, and metastasis. Different agents were developed …

Adrenomedullin–new perspectives of a potent peptide hormone

R Schönauer, S Els‐Heindl… - Journal of Peptide …, 2017 - Wiley Online Library
Adrenomedullin (ADM) is a 52‐amino acid multifunctional peptide, which belongs to the
calcitonin gene‐related peptide (CGRP) superfamily of vasoactive peptide hormones. ADM …

Bench-to-bedside pharmacology of adrenomedullin

J Kato, K Kitamura - European journal of pharmacology, 2015 - Elsevier
The bioactive peptide adrenomedullin (AM) exerts pleiotropic actions in various organs and
tissues. In the heart, AM has an inhibitory effect on ventricular remodeling, suppressing …

Targeting adrenomedullin in oncology: A feasible strategy with potential as much more than an alternative anti-angiogenic therapy

R Vázquez, ME Riveiro, C Berenguer-Daize… - Frontiers in …, 2021 - frontiersin.org
The development, maintenance and metastasis of solid tumors are highly dependent on the
formation of blood and lymphatic vessels from pre-existing ones through a series of …

HIF-dependent mechanisms of relationship between hypoxia tolerance and tumor development

DS Dzhalilova, OV Makarova - Biochemistry (Moscow), 2021 - Springer
Oxygen deficiency is one of the key pathogenetic factors determining development and
severity of many diseases, including inflammatory, infectious diseases, and cancer. Lack of …

Peptidergic systems and cancer: Focus on tachykinin and calcitonin/calcitonin gene-related peptide families

ML Sánchez, FD Rodríguez, R Coveñas - Cancers, 2023 - mdpi.com
Simple Summary Neurokinins A and B, adrenomedullin, adrenomedullin 2, amylin, and
calcitonin gene-related peptide are essential in different tumors. These peptides are …