Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021

I Djuricic, PC Calder - Nutrients, 2021 - mdpi.com
Oxidative stress and inflammation have been recognized as important contributors to the risk
of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate …

Oxidation of polyunsaturated fatty acids to produce lipid mediators

WW Christie, JL Harwood - Essays in biochemistry, 2020 - portlandpress.com
The chemistry, biochemistry, pharmacology and molecular biology of oxylipins (defined as a
family of oxygenated natural products that are formed from unsaturated fatty acids by …

Bioactive lipids, inflammation and chronic diseases

A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Leukocytes, systemic inflammation and immunopathology in acute-on-chronic liver failure

M Casulleras, IW Zhang, C López-Vicario, J Clària - Cells, 2020 - mdpi.com
Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with
cirrhosis and is characterized by acute decompensation, organ failure (s) and high short …

N-3 polyunsaturated fatty acids and the resolution of neuroinflammation

C Joffre, C Rey, S Layé - Frontiers in pharmacology, 2019 - frontiersin.org
In the past few decades, as a result of their anti-inflammatory properties, n-3 long chain
polyunsaturated fatty acids (n-3 LC-PUFAs), have gained greater importance in the …

Loss of hepatic Mboat7 leads to liver fibrosis

VR Thangapandi, O Knittelfelder, M Brosch… - Gut, 2021 - gut.bmj.com
Objective The rs641738C> T variant located near the membrane-bound O-acyltransferase
domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including …

Chronic inflammation in PCOS: the potential benefits of specialized pro-resolving lipid mediators (SPMs) in the improvement of the resolutive response

PA Regidor, A Mueller, M Sailer… - International Journal of …, 2020 - mdpi.com
PCOS as the most common endocrine disorder of women in their reproductive age affects
between 5–15% of the female population. Apart from its cardinal symptoms, like irregular …

High and low molecular weight hyaluronic acid differentially influences oxylipins synthesis in course of neuroinflammation

DV Chistyakov, AA Astakhova, NV Azbukina… - International journal of …, 2019 - mdpi.com
Hyaluronic acid (HA), a major glycosaminoglycan of the extracellular matrix, has cell
signaling functions that are dependent on its molecular weight. Anti-inflammatory effects for …

Hypoxia‐inducible factor 1‐alpha (HIF‐1α) as a factor mediating the relationship between obesity and heart failure with preserved ejection fraction

I Warbrick, SW Rabkin - Obesity Reviews, 2019 - Wiley Online Library
Heart failure with preserved ejection fraction (HFpEF), a common condition with an
increased mortality, is strongly associated with obesity and the metabolic syndrome. The …

Roles of resolvins in chronic inflammatory response

C Liu, D Fan, Q Lei, A Lu, X He - International journal of molecular …, 2022 - mdpi.com
An inflammatory response is beneficial to the organism, while an excessive uncontrolled
inflammatory response can lead to the nonspecific killing of tissue cells. Therefore …