The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …
Polygenic risk scores in clinical psychology: bridging genomic risk to individual differences
R Bogdan, DAA Baranger… - Annual review of clinical …, 2018 - annualreviews.org
Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex
The genetic etiology of autism spectrum disorder (ASD) is multifactorial, but how
combinations of genetic factors determine risk is unclear. In a large family sample, we show …
combinations of genetic factors determine risk is unclear. In a large family sample, we show …
Distinguishing genetic correlation from causation across 52 diseases and complex traits
LJ O'Connor, AL Price - Nature genetics, 2018 - nature.com
Mendelian randomization, a method to infer causal relationships, is confounded by genetic
correlations reflecting shared etiology. We developed a model in which a latent causal …
correlations reflecting shared etiology. We developed a model in which a latent causal …
Next-generation sequencing strategies
SE Levy, BE Boone - Cold Spring Harbor …, 2019 - perspectivesinmedicine.cshlp.org
More than a decade ago, the term “next-generation” sequencing was coined to describe
what was, at the time, revolutionary new methods to sequence RNA and DNA at a faster …
what was, at the time, revolutionary new methods to sequence RNA and DNA at a faster …
An evolutionary perspective on complex neuropsychiatric disease
The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …
architecture of human traits, including the genetic architecture of complex neuropsychiatric …
Parental age and differential estimates of risk for neuropsychiatric disorders: Findings from the Danish birth cohort
Objective Parental age at birth has been shown to affect the rates of a range of
neurodevelopmental disorders, but the understanding of the mechanisms through which it …
neurodevelopmental disorders, but the understanding of the mechanisms through which it …
The shared genetic architecture of schizophrenia, bipolar disorder and lifespan
Psychiatric disorders such as Schizophrenia (SCZ) and Bipolar Disorder (BD) represent an
evolutionary paradox, as they exhibit strong negative effects on fitness, such as decreased …
evolutionary paradox, as they exhibit strong negative effects on fitness, such as decreased …
Paternal age and 13 psychiatric disorders in the offspring: a population-based cohort study of 7 million children in Taiwan
Although paternal age has been linked to certain psychiatric disorders, the nature of any
causal relationship remains elusive. Here, we aimed to comprehensively assess the …
causal relationship remains elusive. Here, we aimed to comprehensively assess the …
Neuro-transcriptomic signatures for mood disorder morbidity and suicide mortality
Suicidal behaviors are strongly linked with mood disorders, but the specific neurobiological
and functional gene-expression correlates for this linkage remain elusive. We performed …
and functional gene-expression correlates for this linkage remain elusive. We performed …