Collagen is the most abundant protein in mammals, often serving as the main load bearing
constituent in soft tissues. Collagen undergoes continuous remodeling processes in which …

The development of the vascular system was a critical step in the evolution of species. It
allowed organisms to meet the growing metabolic demands and opened the door for the …

The development and subsequent rupture of atherosclerotic plaques in human carotid
arteries is a major cause of ischaemic stroke. Mechanical characterization of atherosclerotic …

Advanced imaging techniques, novel experimental approaches and sophisticated
computational modeling frameworks to characterize and simulate the mechanical behavior …

Abdominal aortic aneurysms (AAAs) are a local dilation of the aorta and are associated with
significant mortality due to rupture and treatment complications. There is a need for less …

Atherosclerotic plaque rupture in carotid arteries can lead to stroke which is one of the
leading causes of death or disability worldwide. The accumulation of atherosclerotic plaque …

Cerebral aneurysms are abnormal dilations of blood vessels in the brain found in 2% of the
population. While rupture is rare, it is fatal or will most likely cause neurological deficits. The …

This chapter addresses the active properties of blood vessels with a focus on vasoreactivity
and arteriogenesis. We review the structure and function of Smooth Muscle Cells (SMC) and …