Genome-scale metabolic models (GEMs) are computational representations that enable
mathematical exploration of metabolic behaviors within cellular and environmental …

Shikimic acid (SA), a hydroaromatic natural product, is used as a chiral precursor for organic
synthesis of oseltamivir (Tamiflu®, an antiviral drug). The process of microbial production of …

Cinnamaldehyde (CAD) derived from cinnamon bark has received much attention for its
potential as a nematicide and food additive. Previously, we have succeeded in developing …

Chlorogenic acid is a natural phenolic compound widely used in the food and daily chemical
industries. Compared to plant extraction, microbial cell factories provide a green and …

Advances in synthetic biology and artificial intelligence (AI) have provided new opportunities
for modern biotechnology. High-performance cell factories, the backbone of industrial …

Abstract Protocatechuic acid (3, 4-dihydroxybenzoic acid, PCA) is widely used in the
pharmaceuticals, health food, and cosmetics industries owing to its diverse biological …

Hydroxytyrosol is a natural polyphenolic compound widely used in the food and drug
industries. The current commercial production of hydroxytyrosol relies mainly on plant …

l-Phenylalanine (l-Phe) is widely used in the food and pharmaceutical industries. However,
the biosynthesis of l-Phe using Escherichia coli remains challenging due to its lower …

The construction of high-performance microbial cell factories (MCFs) is the centerpiece of
biomanufacturing. However, the complex metabolic regulatory network of microorganisms …

Cis, cis-muconic acid (MA) is widely used as a key starting material in the synthesis of
diverse polymers. The growing demand in these industries has led to an increased need for …