Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The
15 mammalian galectins have either one or two conserved carbohydrate recognition …

Background & Aims Increased levels of galectin 3 have been associated with nonalcoholic
steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 …

Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is
driven by intercellular adhesions, cell contractility, and forces generated within the …

Galectin 3 is a member of a family of β-galactoside binding proteins and has emerged as an
important regulator of diverse functions critical in cancer biology including apoptosis …

Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

An essential property of the plasma membrane of mammalian cells is its plasticity, which is
required for sensing and transmitting of signals, and for accommodating the tensional …

Glycosylation is a common posttranslational modification of proteins and lipids of the
secretory pathway that generates binding sites for galactose-specific lectins or galectins …

Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids
that are involved in the lateral compartmentalization of molecules at the cell surface …

Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness;
however, the underlying mechanisms are unclear. Here, we showed that β1 integrin and …