Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …

Targeted protein degradation (TPD) has been established as a viable alternative to
attenuate the function of a specific protein of interest in both biological and clinical contexts …

Protein misfolding is a major driver of ageing‐associated frailty and disease pathology.
Although all cells possess multiple, well‐characterised protein quality control systems to …

Abstract Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two
catalytic domains and a zinc-finger ubiquitin binding domain (ZnF-UBP) domain. The …

Dysregulated proteostasis is one of the hallmarks of ageing. Damaged proteins may impair
cellular function and their accumulation may lead to tissue dysfunction and disease. This is …

Proteasome subunit alpha type-2 (PSMA2) is a critical component of the 20S proteasome,
which is the core particle of the 26S proteasome complex and is involved in cellular protein …

Over 600 E3 ligases in humans execute ubiquitination of specific target proteins in a
spatiotemporal manner to elicit desired signaling effects. Here, we developed a ubiquitin …

Changing physiological conditions can increase the need for protein degradative capacity in
eukaryotic cells. Both the ubiquitin-proteasome system and autophagy contribute to protein …

The autophagy-lysosome pathway plays an indispensable role in the protein quality control
by degrading abnormal organelles and proteins including a-synuclein (aSyn) associated …