Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder

P Abrams, KE Andersson, JJ Buccafusco… - British journal of …, 2006 - Wiley Online Library
1 The effectiveness of antimuscarinic agents in the treatment of the overactive bladder (OAB)
syndrome is thought to arise through blockade of bladder muscarinic receptors located on …

Muscarinic receptor antagonists for overactive bladder

P Abrams, KE Andersson - BJU international, 2007 - Wiley Online Library
From time to time we publish a full review of drugs that are available for the treatment of
common conditions. In this issue, the review is written by two of the leading authorities in the …

Anticholinergic activity of 107 medications commonly used by older adults

ML Chew, BH Mulsant, BG Pollock… - Journal of the …, 2008 - Wiley Online Library
The objective of this study was to measure the anticholinergic activity (AA) of medications
commonly used by older adults. A radioreceptor assay was used to investigate the AA of 107 …

[PDF][PDF] The pharmacological treatment of urinary incontinence

KE Andersson, R Appell, LD Cardozo, C Chapple… - BJU …, 1999 - academia.edu
The pharmacological treatment of urinary incontinence Page 1 BJU International (1999), 84,
923–947 REVIEW The pharmacological treatment of urinary incontinence K.-E …

Darifenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder

F Haab, L Stewart, P Dwyer - European urology, 2004 - Elsevier
Objectives: To evaluate the efficacy, tolerability and safety of darifenacin, a once-daily M3
selective receptor antagonist (M3 SRA), in patients with overactive bladder (OAB). Methods …

Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients

GG Kay, MB Abou‐Donia, WS Messer Jr… - Journal of the …, 2005 - Wiley Online Library
Antimuscarinic agents are the predominant pharmacological treatment for patients with
overactive bladder (OAB). These drugs are thought to act primarily through antagonism at …

Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence

KE Andersson, CR Chapple, L Cardozo… - Current opinion in …, 2009 - journals.lww.com
Pharmacological treatment of overactive bladder: report from... : Current Opinion in Urology
Pharmacological treatment of overactive bladder: report from the International Consultation on …

Trospium chloride has no effect on memory testing and is assay undetectable in the central nervous system of older patients with overactive bladder

D Staskin, G Kay, C Tannenbaum… - … journal of clinical …, 2010 - Wiley Online Library
Background: Muscarinic receptors in the brain play an important role in cognitive function,
especially memory, and there is growing awareness that specific antimuscarinic drugs for …

Effect of mirabegron on cognitive function in elderly patients with overactive bladder: MoCA results from a phase 4 randomized, placebo-controlled study (PILLAR)

TL Griebling, NL Campbell, J Mangel, D Staskin… - BMC geriatrics, 2020 - Springer
Background Antimuscarinics are often used for treatment of overactive bladder (OAB), but
exposure to medications such as antimuscarinics that have anticholinergic properties has …

Assessment of cognitive function of the elderly population: effects of darifenacin

RB Lipton, K Kolodner, K Wesnes - The Journal of urology, 2005 - auajournals.org
Purpose: Overactive bladder is common in the elderly population, which is susceptible to
cognitive disorders and drug induced cognitive impairment. Existing overactive bladder …