Liquid–liquid phase separation in tumor biology
X Tong, R Tang, J Xu, W Wang, Y Zhao, X Yu… - Signal Transduction and …, 2022 - nature.com
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …
Neurodegenerative diseases: expanding the prion concept
LC Walker, M Jucker - Annual review of neuroscience, 2015 - annualreviews.org
The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
KM Farmer, G Ghag, N Puangmalai… - Acta neuropathologica …, 2020 - Springer
The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …
genome integrity, including cell cycle control, DNA damage response, and apoptosis …
Treating p53 mutant aggregation-associated cancer
M Kanapathipillai - Cancers, 2018 - mdpi.com
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell
growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its …
growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its …
p53 isoforms and their implications in cancer
M Vieler, S Sanyal - Cancers, 2018 - mdpi.com
In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …
p53 amyloid aggregation in cancer: function, mechanism, and therapy
J Li, M Guo, L Chen, Z Chen, Y Fu, Y Chen - Experimental Hematology & …, 2022 - Springer
Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has
been proposed in recent years. p53, the most well-known tumor suppressor, has been …
been proposed in recent years. p53, the most well-known tumor suppressor, has been …
Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer
LW Zheng, CC Liu, KD Yu - Journal of Hematology & Oncology, 2023 - Springer
Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …
[HTML][HTML] TP53 mutations in epithelial ovarian cancer
Y Zhang, L Cao, D Nguyen, H Lu - Translational cancer research, 2016 - ncbi.nlm.nih.gov
Genomic sequencing analyses of a variety of human cancers have revealed that massive
mutations of cancer-relevant genes are the major alterations in cancerous cells, and their …
mutations of cancer-relevant genes are the major alterations in cancerous cells, and their …
Prion-like aggregation of mutant p53 in cancer
p53 is a master regulatory protein that participates in cellular processes such as apoptosis,
DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and …
DNA repair, and cell cycle control. p53 functions as a homotetrameric tumor suppressor, and …
Aberrant phase separation and cancer
K Taniue, N Akimitsu - The FEBS journal, 2022 - Wiley Online Library
Eukaryotic cells are intracellularly divided into numerous compartments or organelles, which
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …