In pharmaceutical research and development, various new chemical entities (NCE) are
found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher …

A reduction in particle size improves the solubility and bioavailability of pharmaceuticals.
The traditional methods utilized in this regard are associated with problems so the use of …

Reducing the size of pharmaceutical particles is an approved way to enhance solubility and
bioavailability of a drug, leading to a decrease in the drug dose and its side effects. In this …

This review considers advances in the understanding of active pharmaceutical ingredient
polymorphism since around 2010 mainly from a structural view point, with a focus on twelve …

The preparation of pharmaceutical co-crystals using supercritical CO2 (scCO2) is reviewed.
Co-crystallization is an emerging and powerful technique to improve the physicochemical …

Cocrystals of itraconazole, an antifungal drug with poor bioavailability, and succinic acid, a
water-soluble dicarboxylic acid, were formed by gas antisolvent (GAS) cocrystallization …

Crystallization from the melt can allow the achievement of high driving force for
crystallization accompanied by relatively slow growth, nucleation, and transformation rates …

Cocrystals of itraconazole, an antifungal drug with poor aqueous solubility, and l-malic acid
were prepared in tetrahydrofuran (THF) using CO2 as an antisolvent. Using the gas …

Crystallization assisted by supercritical CO 2 has been long ago developed for micronization
purposes, but its application to fabricate cocrystals is in its infancy. In this work, the …

Gas antisolvent (GAS), based on antisolvent feature of supercritical CO 2, was unlikely
explored to obtain cocrystals of quercetin/nicotinamide (QUE/NIC). Cocrystallization is an …