Physiological insights into all-trans-retinoic acid biosynthesis
JL Napoli - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
All-trans-retinoic acid (atRA) provides essential support to diverse biological systems and
physiological processes. Epithelial differentiation and its relationship to cancer, and …
physiological processes. Epithelial differentiation and its relationship to cancer, and …
Vitamin A and retinoid signaling in the kidneys
KM DiKun, LJ Gudas - Pharmacology & Therapeutics, 2023 - Elsevier
Vitamin A (VA, retinol) and its metabolites (commonly called retinoids) are required for the
proper development of the kidney during embryogenesis, but retinoids also play key roles in …
proper development of the kidney during embryogenesis, but retinoids also play key roles in …
[HTML][HTML] Role of Nampt-Sirt6 axis in renal proximal tubules in extracellular matrix deposition in diabetic nephropathy
H Muraoka, K Hasegawa, Y Sakamaki, H Minakuchi… - Cell Reports, 2019 - cell.com
Nicotinamide adenine dinucleotide (NAD+) metabolism plays a critical role in kidneys. We
previously reported that decreased secretion of a NAD+ precursor, nicotinamide …
previously reported that decreased secretion of a NAD+ precursor, nicotinamide …
Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways
LA Denner, J Rodriguez-Rivera… - Journal of …, 2012 - Soc Neuroscience
We previously reported that the peroxisome proliferator-activated receptor γ (PPARγ)
agonist rosiglitazone (RSG) improved hippocampus-dependent cognition in the Alzheimer's …
agonist rosiglitazone (RSG) improved hippocampus-dependent cognition in the Alzheimer's …
The pathogenesis of malaria: a new perspective
AR Mawson - Pathogens and global health, 2013 - Taylor & Francis
With 3· 3 billion people at risk of infection, malaria remains one of the world's most significant
health problems. Increasing resistance of the main causative parasite to currently available …
health problems. Increasing resistance of the main causative parasite to currently available …
Disparate roles of retinoid acid signaling molecules in kidney disease
A Chen, Y Liu, Y Lu, K Lee… - American Journal of …, 2021 - journals.physiology.org
Retinoid acid (RA) is synthesized mainly in the liver and has multiple functions in
development, cell differentiation and proliferation, and regulation of inflammation. RA has …
development, cell differentiation and proliferation, and regulation of inflammation. RA has …
Retinoic acid receptor α activity in proximal tubules prevents kidney injury and fibrosis
KM DiKun, XH Tang, L Fu, ME Choi… - Proceedings of the …, 2024 - National Acad Sciences
Chronic kidney disease (CKD) is characterized by a gradual loss of kidney function and
affects~ 13.4% of the global population. Progressive tubulointerstitial fibrosis, driven in part …
affects~ 13.4% of the global population. Progressive tubulointerstitial fibrosis, driven in part …
Retinoids augment the expression of podocyte proteins by glomerular parietal epithelial cells in experimental glomerular disease
J Zhang, JW Pippin, MR Vaughan, RD Krofft… - Nephron Experimental …, 2012 - karger.com
Background/Aims: A decrease in glomerular podocyte number in membranous nephropathy
and focal segmental glomerulosclerosis (FSGS) ultimately underlines glomerulosclerosis …
and focal segmental glomerulosclerosis (FSGS) ultimately underlines glomerulosclerosis …
[HTML][HTML] Altered lipid metabolism in the aging kidney identified by three layered omic analysis
F Braun, MM Rinschen, V Bartels, P Frommolt… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Aging-associated diseases and their comorbidities affect the life of a constantly growing
proportion of the population in developed countries. At the center of these comorbidities are …
proportion of the population in developed countries. At the center of these comorbidities are …
Vitamin A and diabetes
Y Zhang, T Wang, X Hu, G Chen - Journal of medicinal food, 2021 - liebertpub.com
Recently, research data have shown that vitamin A (VA, retinol) as a micronutrient
participates in the regulation of glucose and lipid metabolism. Since diabetes is a metabolic …
participates in the regulation of glucose and lipid metabolism. Since diabetes is a metabolic …