The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …

Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects
in preclinical studies, but the exact molecular mechanisms of the antidepressant effects …

The histone deacetylases (HDACs) family of enzymes possess deacylase activity for histone
and nonhistone proteins; HDAC11 is the latest discovered HDAC and the only member of …

The TET family of dioxygenases promote DNA demethylation by oxidizing 5-methylcytosine
to 5-hydroxymethylcytosine (5hmC). Hypothalamic agouti-related peptide–expressing …

Abstract Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase predominantly
expressed in the brain. Mutations of the CDKL5 gene lead to CDKL5 disorder, a …

For the past decade protein acetylation has been shown to be a crucial post-transcriptional
modification involved in the regulation of protein functions. Histone acetyltransferases …

Narrow therapeutic window limits treatments with thrombolysis and neuroprotection for most
stroke patients. Widening therapeutic window remains a critical challenge. Understanding …