Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

In 1907, Alois Alzheimer described the case of a 51 year old woman who presented with a
relatively rapidly deteriorating memory along with psychiatric disturbances. She died four …

N-methyl-d-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous
CNS disorders ranging from acute neurodegeneration (eg stroke and trauma), chronic …

The basal ganglia circuitry processes the signals that flow from the cortex, allowing the
correct execution of voluntary movements. In Parkinson's disease, the degeneration of …

Abstract l-Glutamate is the most abundant of a group of endogenous amino acids in the
mammalian central nervous system which presumably function as excitatory …

Memantine is a clinically useful drug in many neurological disorders, including Alzheimer's
disease. The principal mechanism of action of memantine is believed to be the blockade of …

Excessive activation of NMDA receptors is thought to mediate the calcium-dependent
neurotoxicity associated with hypoxic-ischemic brain injury, trauma, epilepsy, and several …