The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Expansion microscopy enables nanoimaging with conventional microscopes by physically
and isotropically magnifying preserved biological specimens embedded in a crosslinked …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …

Congenital heart disease is the most common birth defect, and because of major advances
in medical and surgical management, there are now more adults living with congenital heart …

Muco-Obstructive Lung Diseases This review covers the normal mechanisms of mucus
formation and how they are abnormal in common conditions—such as COPD, cystic fibrosis …

Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …