Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Structural understanding of SARS-CoV-2 virus entry to host cells

K Le, S Kannappan, T Kim, JH Lee, HR Lee… - Frontiers in Molecular …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …

Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

S Moriyama, Y Anraku, S Taminishi, Y Adachi… - Nature …, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS)
antibodies that exist in diverse individuals as public antibody clones. We rationally selected …

In silico binding affinity of the spike protein with ACE2 and the relative evolutionary distance of S gene may be potential factors rapidly obtained for the initial risk of …

A Sugano, J Murakami, H Kataguchi, M Ohta… - Microbial Risk …, 2023 - Elsevier
Objectives In this research, we aimed to find potential factors which are rapidly obtained for
the risk of the coming new variants of severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] Bovine lactoferrin suppresses the cathepsin-dependent pathway of SARS-CoV-2 entry in vitro

M Kobayashi-Sakamoto, T Maeda, J Yusa… - International Dairy …, 2024 - Elsevier
Severe acute respiratory coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019
(COVID-19). The frequent appearance of variants requires adjunct strategies to combat …

Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA. 1

T Ozawa, Y Ikeda, L Chen, R Suzuki, A Hoshino… - Structure, 2024 - cell.com
SARS-CoV-2 rapidly mutates and acquires resistance to neutralizing antibodies. We report
an in-silico-designed antibody that restores the neutralizing activity of a neutralizing …

[HTML][HTML] Virus evolution and reduced viral viability during treatment of persistent COVID-19 Omicron BA. 5 infection in an immunocompromised host

H Kaya, H Tani, N Inasaki, S Yazawa… - International Journal of …, 2023 - Elsevier
We present the clinical course of a 72-year-old female with COVID-19 and a history of
hematologic stem cell transplantation for acute myeloid leukemia. We performed serial …

Neutralizing antibody levels and epidemiological information of patients with breakthrough COVID-19 infection in Toyama, Japan

H Tani, N Inasaki, T Shimada, Y Saga, H Kaya… - bioRxiv, 2023 - biorxiv.org
Breakthrough infection (BI) after coronavirus disease 2019 (COVID-19) vaccination has
exploded owing to the emergence of various SARS-CoV-2 variants and has become a major …

Characteristics of virus and antibody response in an immunocompromised patient with persistent SARS-CoV-2 infection

S Yazawa, K Fukuyama, R Kawakami… - Journal of Infection and …, 2024 - Elsevier
We have previously reported a clinical case in which a hospitalized patient with a history of
hematopoietic stem cell transplantation for acute myeloid leukemia was persistently infected …

Neutralizing antibody levels and epidemiological characteristics of patients with breakthrough COVID-19 infection in Toyama, Japan

H Tani, N Inasaki, S Yazawa, T Shimada… - Japanese Journal of …, 2023 - jstage.jst.go.jp
抄録 Breakthrough infection (BI) after coronavirus disease 2019 (COVID-19) vaccination has
increased owing to the emergence of novel SARS-CoV-2 variants. In this study, we analyzed …