MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Autophagy act as a double-edged sword in cancer with both tumor promoting and inhibiting
roles. Under normal conditions of autophagy, the damaged cell organelles and other debris …

Tissues in multicellular organisms are populated by resident macrophages, which perform
both generic and tissue‐specific functions. The latter are induced by signals from the …

Aberrant enhancer activation is a key mechanism driving oncogene expression in many
cancers. While much is known about the regulation of larger chromosome domains in …

Histone lysine methylation functions at the interface of the extracellular environment and
intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a …

Despite growing awareness of the biologic features underlying MLL-rearranged leukemia,
targeted therapies for this leukemia have remained elusive and clinical outcomes remain …

Pharmacologic targeting of chromatin-associated protein complexes has shown significant
responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance …

Mixed-lineage leukemia (MLL) fuses with a variety of partners to produce a functionally
altered MLL complex that is not expressed in normal cells, which transforms normal …

The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various
functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to …

Abstract Multimerin-1 (MMRN1) is a platelet protein with a role in haemostasis and
coagulation. It is also present in endothelial cells (ECs) and the extracellular matrix (ECM) …