Postmeiotic spermatids use a unique strategy to coordinate gene expression with
morphological transformation, in which transcription and translation take place at separate …

Molecular studies of meiosis in mammals have been long relegated due to some intrinsic
obstacles, namely the impossibility to reproduce the process in vitro, and the difficulty to …

Male gametogenesis, spermatogenesis, is a stepwise developmental process to generate
mature sperm. The most intricate process of spermatogenesis is meiosis during which two …

The testis is pivotal for male reproduction, and its progressive functional decline in aging is
associated with infertility. However, the regulatory mechanism underlying primate testicular …

Round spermatid injection (ROSI) results in a lower birth rate than intracytoplasmic sperm
injection, which has hampered its clinical application. Inefficient development of ROSI …

Mammalian spermatogenesis shows prominent chromatin and transcriptomic switches in
germ cells, but it is unclear how such dynamics are controlled. Here we identify RNA …

During human spermatogenesis, germ cells undergo dynamic changes in chromatin
organization/re-packaging and in transcriptomes. In order to better understand the …

Pachytene piRNA biogenesis is a hallmark of the germline, distinct from another wave of pre-
pachytene piRNA biogenesis with regard to the lack of a secondary amplification process …

Epigenetic regulation of gene expression is tightly controlled by the dynamic modification of
histones by chemical groups, the diversity of which has largely expanded over the past …

The transition from meiotic spermatocytes to postmeiotic haploid germ cells constitutes an
essential step in spermatogenesis. The epigenomic regulatory mechanisms underlying this …