Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

Breast cancer is the most frequent cancer among women, and metastases in distant organs
are the leading cause of the cancer‐related deaths. While survival of early‐stage breast …

Tumor-draining lymph nodes (LNs) play a crucial role during cancer spread and in initiation
of anti-cancer adaptive immunity. Neutrophils form a substantial population of cells in LNs …

HMGB1 is a member of highly conserved high mobility group protein superfamily with
intracellular and extracellular distribution. Abnormal HMGB1 levels are frequently …

Breast cancer is the most commonly diagnosed cancer in the world, and metastasis is often
the main cause of death in breast cancer patients. Salvia miltiorrhiza-Ginseng (SG) herb pair …

Progression from localized to metastatic disease requires cancer cells spreading to distant
organs through the bloodstream. Only a small proportion of these circulating tumor cells …

Organ-specific metastasis to secondary organs is dependent on the formation of a
supportive pre-metastatic niche. This tissue-specific microenvironmental response is thought …

Gastric cancer (GC) with pulmonary metastasis is one of the deadliest diseases in the world;
however, the underlying pathological mechanisms and potential therapeutic targets remain …

During breast cancer development, programmed cell death 1 ligand 1 (PD-L1)
overexpression in neutrophils leads to delayed apoptosis and promotes neutrophil …