The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Single-cell gene expression technologies are powerful tools to study cell types in the human
brain, but efforts have largely focused on cortical brain regions. We therefore created a …

Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in
response to all CNS injuries and diseases. To better understand the reactive astrocyte state …

The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's
disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue …

Cellular diversity and architectural complexity create barriers to understanding the function
of the mammalian CNS at a molecular level. To address this problem, we have recently …

The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal
projection systems—so-called direct and indirect pathways—form the functional backbone of …

The nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two
subpopulations of nucleus accumbens projection neurons, those expressing dopamine D1 …