Aptamers come of age–at last

DHJ Bunka, PG Stockley - Nature Reviews Microbiology, 2006 - nature.com
Nucleic-acid aptamers have the molecular recognition properties of antibodies, and can be
isolated robotically for high-throughput applications in diagnostics, research and …

[HTML][HTML] Aptamers in diagnostics and treatment of viral infections

T Wandtke, J Woźniak, P Kopiński - Viruses, 2015 - mdpi.com
Aptamers are in vitro selected DNA or RNA molecules that are capable of binding a wide
range of nucleic and non-nucleic acid molecules with high affinity and specificity. They have …

Pharmacokinetics of a cholesterol-conjugated aptamer against the hepatitis C virus (HCV) NS5B protein

CH Lee, SH Lee, JH Kim, YH Noh, GJ Noh… - … Therapy-Nucleic Acids, 2015 - cell.com
Hepatitis C virus (HCV) is the major cause of progressive liver disease such as chronic
hepatitis, cirrhosis, and hepatocellular carcinoma. Previously, we reported that a 29 …

Use of aptamers as diagnostics tools and antiviral agents for human viruses

VM González, ME Martín, G Fernández… - Pharmaceuticals, 2016 - mdpi.com
Appropriate diagnosis is the key factor for treatment of viral diseases. Time is the most
important factor in rapidly developing and epidemiologically dangerous diseases, such as …

Aptamers for anti-viral therapeutics and diagnostics

TH Kim, SW Lee - International Journal of Molecular Sciences, 2021 - mdpi.com
Viral infections cause a host of fatal diseases and seriously affect every form of life from
bacteria to humans. Although most viral infections can receive appropriate treatment thereby …

Survey of the year 2005 commercial optical biosensor literature

RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2006 - Wiley Online Library
Abstract We identified 1113 articles (103 reviews, 1010 primary research articles) published
in 2005 that describe experiments performed using commercially available optical …

Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases

Q Pan, F Luo, M Liu, XL Zhang - Journal of Infection, 2018 - Elsevier
The entire human population is at risk of infectious diseases worldwide. Thus far, the
diagnosis and treatment of human infectious diseases at the molecular and nanoscale …

Aptamer-based antibacterial and antiviral therapy against infectious diseases

XF Chen, X Zhao, Z Yang - Journal of Medicinal Chemistry, 2021 - ACS Publications
Nucleic acid aptamers are single-stranded DNA or RNA molecules selected in vitro that can
bind to a broad range of targets with high affinity and specificity. As promising alternatives to …

Aptamer-based therapeutics: new approaches to combat human viral diseases

KT Shum, J Zhou, JJ Rossi - Pharmaceuticals, 2013 - mdpi.com
Viruses replicate inside the cells of an organism and continuously evolve to contend with an
ever-changing environment. Many life-threatening diseases, such as AIDS, SARS, hepatitis …

Nanopore-based conformational analysis of a viral RNA drug target

C Shasha, RY Henley, DH Stoloff, KD Rynearson… - ACS …, 2014 - ACS Publications
Nanopores are single-molecule sensors that show exceptional promise as a biomolecular
analysis tool by enabling label-free detection of small amounts of sample. In this paper, we …