Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the
methylation of lysine 27 on histone H3 (H3K27me). This histone modification is a feature of …

Polycomb repressive complex 2 (PRC2) and its histone H3 lysine-27 methylation activity are
crucial for multicellular development by virtue of their role in maintaining transcriptional …

The dynamic structure of histones and DNA, also known as chromatin, is regulated by two
classes of enzymes: those that mediate covalent modifications on either histone proteins or …

Weaver syndrome (WS) is a rare congenital overgrowth disorder caused by heterozygous
mutations in EZH2 (enhancer of zeste homolog 2) or EED (embryonic ectoderm …

In late 2012 it was evidenced that most of the human genome is transcribed but only a small
percentage of the transcripts are translated. This observation supported the importance of …

Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved
multi-subunit complexes that repress gene transcription by introducing trimethylation of …

Histone-modifying enzymes are required for cell identity and lineage commitment, however
little is known about the regulatory origins of the epigenome during embryonic development …

Compared to enhancers, silencers are notably difficult to identify and validate
experimentally. In search for human silencers, we utilized H3K27me3-DNase I …

The past decade brought a revolution in understanding of the structure, topology and
disease-inducing lesions of RNA and DNA, fueled by unprecedented progress in next …