The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

An increasing variety of indicators of antimicrobial usage has become available in human
and veterinary medicine, with no consensus on the most appropriate indicators to be used …

We study an infection-age model of disease transmission, where both the infectiousness
and the removal rate may depend on the infection age. In order to study persistence, the …

The emergence of resistant pathogens in response to selection pressure by drugs and their
possible disappearance when drug use is discontinued are evolutionary processes common …

Background Reducing antibiotic treatment duration is a key component of hospital antibiotic
stewardship interventions. However, its effectiveness in reducing antimicrobial resistance is …

Abstract Background. Methicillin-resistant Staphylococcus aureus (MRSA) has traditionally
been associated with infections in hospitals. Recently, a new strain of MRSA has emerged …

Background Dynamic transmission models are increasingly being used to improve our
understanding of the epidemiology of healthcare-associated infections (HCAI). However …

BACKGROUND The effects of antibiotics on infant gut microbiota are unclear. We
hypothesized that the use of common antibiotics results in long-term aberration in gut …

The successful treatment of bacterial infections is the product of a collaboration between
antibiotics and the host's immune defenses. Nevertheless, in the design of antibiotic …

The evolution of resistance to antibiotics is a major public health problem and an example of
rapid adaptation under natural selection by antibiotics. The dynamics of antibiotic resistance …