The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Kir4. 1 is an inwardly rectifying K+ channel expressed exclusively in glial cells in the central
nervous system. In glia, Kir4. 1 is implicated in several functions including extracellular K+ …

Initial biophysical studies on glial cells nearly 50 years ago identified these cells as being
electrically silent. These first studies also demonstrated a large K+ conductance, which led …

The blood–brain barrier (BBB) regulates the delivery of oxygen and important nutrients to
the brain through active and passive transport and prevents neurotoxins from entering the …

The glymphatic system is a unique pathway that utilises end-feet Aquaporin 4 (AQP4)
channels within perivascular astrocytes, which is believed to cause cerebrospinal fluid …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder in which patients lose
motor functions due to progressive loss of motor neurons in the cortex, brainstem, and spinal …

Diversified neurons are essential for sensorimotor function, but whether astrocytes become
specialized to optimize circuit performance remains unclear. Large fast α-motor neurons …

There is strong evidence for blood-brain and blood-spinal cord barrier dysfunction at the
early stages of many neurodegenerative diseases, including amyotrophic lateral sclerosis …

Since the discovery of aquaporins, it has become clear that the various mammalian
aquaporins play critical physiological roles in water and ion balance in multiple tissues …