Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

As part of the innate immune system, complement plays a critical role in the elimination of
pathogens and mobilization of cellular immune responses. In the central nervous system …

Background Circadian rhythms broadly impact human health by regulating our daily
physiological and metabolic processes. The circadian clocks substantially regulate our …

The complexity of the Plasmodium parasite and its life cycle poses a challenge to our
understanding of the host immune response against malaria. Studying human immune …

Management of severe malaria remains a critical global challenge. In this study, using a
multiplexed quantitative proteomics pipeline we systematically investigated the plasma …

The complement system exerts crucial functions both in innate immune responses and
adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen …

Severe malaria (SM) has high mortality and morbidity rates despite treatment with potent
antimalarials. Disease onset and outcome is dependent upon both parasite and host factors …

Background Cerebral malaria is often pronounced as a major life-threatening neurological
complication of Plasmodium falciparum infection. The complex pathogenic landscape of the …

There is currently a global effort to reduce malaria morbidity and mortality. However, malaria
still results in the deaths of thousands of people every year. Malaria is caused by …

Rabies is a fatal encephalitis caused by the Rabies lyssavirus (RABV). The presence of
minimal neuropathological changes observed in rabies indicates that neuronal dysfunction …