The role of nitric oxide in innate immunity.
C Bogdan, M Röllinghoff, A Diefenbach - Immunological reviews, 2000 - europepmc.org
Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is
expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L …
expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L …
Interleukin-12: a cytokine at the interface of inflammation and immunity
G Trinchieri - Advances in immunology, 1998 - Elsevier
Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …
A natural model of Leishmania major infection reveals a prolonged “silent” phase of parasite amplification in the skin before the onset of lesion formation and immunity
Y Belkaid, S Mendez, R Lira, N Kadambi… - The Journal of …, 2000 - journals.aai.org
A model of Leishmania major infection in C57BL/6 mice has been established that combines
two main features of natural transmission: low dose (100 metacyclic promastigotes) and …
two main features of natural transmission: low dose (100 metacyclic promastigotes) and …
Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice
S Murosaki, Y Yamamoto, K Ito, T Inokuchi… - Journal of allergy and …, 1998 - Elsevier
Background: Food allergy is caused by production of IgE against dietary antigen induced by
TH2 response. IL-12 inhibits TH2 responses and strongly suppresses IgE production. We …
TH2 response. IL-12 inhibits TH2 responses and strongly suppresses IgE production. We …
Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.
L Carrera, RT Gazzinelli, R Badolato, S Hieny… - The Journal of …, 1996 - rupress.org
Leishmania major promastigotes were found to avoid activation of mouse bone marrow-
derived macrophages (BMM0) in vitro for production of cytokines that are typically induced …
derived macrophages (BMM0) in vitro for production of cytokines that are typically induced …
Dendritic cells, but not macrophages, produce IL‐12 immediately following Leishmania donovani infection
PMA Gorak, CR Engwerda… - European journal of …, 1998 - Wiley Online Library
Infection with Leishmania, an obligate intracellular parasite of mononuclear phagocytes,
stimulates the production of IFN‐γ from NK cells, via a pathway which is dependent upon IL …
stimulates the production of IFN‐γ from NK cells, via a pathway which is dependent upon IL …
Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
JC Aliberti, MA Cardoso, GA Martins… - Infection and …, 1996 - Am Soc Microbiol
Host resistance to infection by Trypanosoma cruzi is dependent on both natural and
acquired immune responses. During the first week of infection in mice, NK cell-derived …
acquired immune responses. During the first week of infection in mice, NK cell-derived …
Cell biology and immunology of Leishmania
E Mougneau, F Bihl, N Glaichenhaus - Immunological reviews, 2011 - Wiley Online Library
More than 20 years ago, immunologists discovered that resistance and susceptibility to
experimental infection with the intracellular protozoan Leishmania major was associated …
experimental infection with the intracellular protozoan Leishmania major was associated …
Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells
F Cardillo, JC Voltarelli, SG Reed… - Infection and …, 1996 - Am Soc Microbiol
Gamma interferon (IFN-gamma) plays an important role in experimental Trypanosoma cruzi
infections, presumably by controlling the early replication of parasites in host macrophages …
infections, presumably by controlling the early replication of parasites in host macrophages …
Immunoregulation by interleukin-12
G Trinchieri, F Gerosa - Journal of Leucocyte Biology, 1996 - academic.oup.com
Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine produced primarily by antigen-
presenting cells (monocytes, macrophages, dendritic cells, and B cells). Its production is …
presenting cells (monocytes, macrophages, dendritic cells, and B cells). Its production is …