The citrus flavonoid nobiletin downregulates angiopoietin-like protein 3 (ANGPTL3) expression and exhibits lipid-modulating effects in hepatic cells and adult …
Nobiletin, a dietary citrus flavonoid, exerts biological activities against hyperlipidemia,
obesity, and atherosclerotic cardiovascular diseases (ASCVDs). The aim of this study was to …
obesity, and atherosclerotic cardiovascular diseases (ASCVDs). The aim of this study was to …
The neuroprotective effects of flavonoid fisetin against corticosterone-induced cell death through modulation of ERK, p38, and PI3K/Akt/FOXO3a-dependent pathways …
The overactive hypothalamic–pituitary–adrenal (HPA) axis is believed to trigger the
overproduction of corticosterone, leading to neurotoxicity in the brain. Fisetin is a flavonoid …
overproduction of corticosterone, leading to neurotoxicity in the brain. Fisetin is a flavonoid …
An integrated multi-omics approach reveals polymethoxylated flavonoid biosynthesis in Citrus reticulata cv. Chachiensis
J Wen, Y Wang, X Lu, H Pan, D Jin, J Wen… - Nature …, 2024 - nature.com
Citrus reticulata cv. Chachiensis (CRC) is an important medicinal plant, its dried mature
peels named “Guangchenpi”, has been used as a traditional Chinese medicine to treat …
peels named “Guangchenpi”, has been used as a traditional Chinese medicine to treat …
Pinostrobin modulates FOXO3 expression, nuclear localization, and exerts antileukemic effects in AML cells and zebrafish xenografts
Acute myeloid leukemia (AML) is a disease characterized by abnormal cell proliferation in
the bone marrow and is the most common quickly progressive leukemia in adults …
the bone marrow and is the most common quickly progressive leukemia in adults …
5-Demethylnobiletin mediates cell cycle arrest and apoptosis via the ERK1/2/AKT/STAT3 signaling pathways in glioblastoma cells
X Zhang, L Zhao, J Xiao, Y Wang, Y Li, C Zhu… - Frontiers in …, 2023 - frontiersin.org
5-Demethylnobiletin is the active ingredient in citrus polymethoxyflavones that could inhibit
the proliferation of several tumor cells. However, the anti-tumor effect of 5-Demethylnobiletin …
the proliferation of several tumor cells. However, the anti-tumor effect of 5-Demethylnobiletin …
GNL3L exhibits pro-tumor activities via NF-κB pathway as a poor prognostic factor in acute myeloid leukemia
J Li, Z Wu, Y Pan, Y Chen, J Chu, Y Cong, Q Fang - Journal of Cancer, 2024 - jcancer.org
Acute myeloid leukemia (AML) is the leukemia with the worst prognosis, and current
knowledge of AML pathogenesis and available therapies for AML remain limited. 40% of …
knowledge of AML pathogenesis and available therapies for AML remain limited. 40% of …
Potential role of nobiletin in Alzheimer's disease
H Fang, L Zhang, H Zhao - Journal of Food Bioactives, 2023 - isnff-jfb.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid plaques
and neurofibrillary tangles. At present, there is no specific drugs for the prevention and …
and neurofibrillary tangles. At present, there is no specific drugs for the prevention and …
Prognostic impact of inhibitors of DNA binding proteins1 and inhibitors of DNA binding proteins4 genes expression on adult Egyptian patients with acute myeloid …
AMN Abdelrahman, AEAMZ Magda… - The Egyptian Journal …, 2024 - journals.lww.com
Background Acute myeloid leukemia (AML) pathogenesis and treatment are currently being
better understood at an accelerated rate. Determining genetic and epigenetic changes that …
better understood at an accelerated rate. Determining genetic and epigenetic changes that …