Bone is one of the most common sites of cancer metastasis in humans and is a significant
source of morbidity and mortality. Bone metastases are considered incurable and result in …

The canine prostate gland shares many morphological and functional similarities with the
human prostate and dogs are the only other large mammals that commonly develop …

BACKGROUND Animal models are important tools to investigate the pathogenesis and
develop treatment strategies for bone metastases in humans. However, there are few …

In determining relative gene expression by quantitative measurements of mRNA levels
using real-time quantitative PCR, internal standards such as reference genes are essential …

BACKGROUND The metastatic potential of a series of prostate cell lines was analysed by
measuring motility and invasiveness, and further correlated to the expression of epithelial …

The purpose of this study was to characterize canine prostate cancer using
immunohistochemical staining specific for acinar and urothelial/ductal tissue and correlate …

Background In this study we try to identify the origin of canine prostate cancer (cPC) by
classifying the tumors histological subtypes and relate these subtypes to their combined …

To reproduce the structural and functional differentiation of human prostatic acini in vivo,
prostatic epithelial and stromal cells derived from human primary cultures were cocultured in …

The high prevalence of prostate cancer (PCa) in elderly men and technical advances in
early detection of localized PCa have led to continued efforts to develop new therapeutic …

Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) of prostate
and urinary bladder are highly invasive and metastatic tumors of closely neighbored organs …