Hemorrhagic transformation (HT) is a frequent complication of acute ischemic stroke that is
especially common after thrombolytic therapy. The risk of HT limits the applicability of tissue …

The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has long been studied in the liver due
to its regulation of plasma low-density lipoprotein cholesterol (LDL-C) and its causal role in …

Background: Frequency and associated risk factors for hemorrhagic transformation (HT), a
worrying complication of ischemic stroke (IS), are not clearly defined. Our aim was to …

Background—PCSK9 loss-of-function (LOF) variants allow for the examination of the effects
of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We …

OBJECTIVE: Preoperative brain injury, particularly stroke and white matter injury, is common
in neonates with congenital heart disease. The objective of this study was to determine the …

Background Predictors and impact of hemorrhagic transformation (HT) after thrombectomy
remain to be elucidated. Objective To investigate the independent predictors and impact of …

Hemorrhagic transformation (HT) is a common complication after thrombolysis with
recombinant tissue-type plasminogen activator (rt-PA) in ischemic stroke. In this article …

Cerebral microbleeds (CMBs) are tiny, round dark-signal lesions that are most often
detected on gradient-echo MR images. CMBs consist of extravasations of blood components …

Background and Purpose An elevated intracellular calcium level is known to be a major
initiator and activator of ischemic cell death pathway; however, in recent studies, elevated …