Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
Abstract α-Amylase is a target for type-2 diabetes mellitus treatment. However, small
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
Synthesis, in vitro α-amylase activity, and molecular docking study of new benzimidazole derivatives
New benzimidazole derivatives were synthesized by reacting substituted phenacyl bromides
with 1 H-benzimidazole-2-thiols. The synthesized compounds were characterized through 1 …
with 1 H-benzimidazole-2-thiols. The synthesized compounds were characterized through 1 …
[HTML][HTML] New benzoxazole-based sulphonamide hybrids analogs as potent inhibitors of α-amylase and α-glucosidase: Synthesis and in vitro evaluation along with in …
The development of drugs resistance in diabetes mellitus is a growing clinical problem,
creates many challenges for patient. To overcome these problems, there is a serious …
creates many challenges for patient. To overcome these problems, there is a serious …
[图书][B] Studies in natural products chemistry
A Rahman - 2023 - books.google.com
Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …
recording of the medicinal properties of natural products, providing cutting-edge accounts of …
Indoles as promising Therapeutics: A review of recent drug discovery efforts
NJ Pravin, RS Kavalapure, SG Alegaon, S Gharge… - Bioorganic …, 2024 - Elsevier
Indole, a fundamental heterocyclic core, has emerged as a cornerstone in the medicinal
chemistry due to its diverse biological activities and structural versatility. This aromatic …
chemistry due to its diverse biological activities and structural versatility. This aromatic …
Dihydropyridines as potential α-amylase and α-glucosidase inhibitors: synthesis, in vitro and in silico studies
Dihydropyridine derivatives 1–31 were synthesized via one-pot solvent free condition and
screened for in vitro against α-amylase and α-glucosidase enzyme. The synthetic derivatives …
screened for in vitro against α-amylase and α-glucosidase enzyme. The synthetic derivatives …
Synthesis of new arylhydrazide bearing Schiff bases/thiazolidinone: α-Amylase, urease activities and their molecular docking studies
Alpha-amylase and urease enzyme over expression endorses various complications like
rheumatoid arthritis, urinary tract infection, colon cancer, metabolic disorder, cardiovascular …
rheumatoid arthritis, urinary tract infection, colon cancer, metabolic disorder, cardiovascular …
New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study
New triazinoindole bearing thiazole/oxazole analogues (1–21) were synthesized and
characterized through spectroscopic techniques such as HREI-MS, 1 H and 13 C NMR. The …
characterized through spectroscopic techniques such as HREI-MS, 1 H and 13 C NMR. The …
Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives
Abstract In this study, 5-amino-nicotinic acid derivatives (1–13) have been designed and
synthesized to evaluate their inhibitory potential against α-amylase and α-glucosidase …
synthesized to evaluate their inhibitory potential against α-amylase and α-glucosidase …
Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
Indazole-based Schiff base analogues (1–27) were synthesized by a three-step reaction
pathway starting from 1-methyl-1H-indazole-3-carboxylic acid as the basic compound. The …
pathway starting from 1-methyl-1H-indazole-3-carboxylic acid as the basic compound. The …