Cell-fate decisions are controlled typically by conserved receptors that interact with co-
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …

Following successful gene rearrangement at αβ T-cell receptor (TCR) loci, developing
thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection …

T cell receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box
p3+ (Foxp3+) regulatory T cells. Several lines of evidence indicate that weak TCR …

Abstract Development of immature T-cell precursors (thymocytes) to either the CD4 helper or
CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major …

Notch is a transmembrane receptor that controls cell fate decisions in Drosophila and whose
role in mammalian cell fate decisions is beginning to be explored. We are investigating the …

T cell specificity and function are linked during development, as MHC-II-specific TCR signals
generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T …

▪ Abstract The two major subsets of T lymphocytes in the peripheral immune system, the
helper and cytotoxic T cells, are defined by their expression of either the CD4 or the CD8 …

The Notch receptor and its ligands are involved in many developmental processes. They are
highly expressed in the thymus and have been implicated in the CD4 versus CD8 lineage …

Macroautophagy serves cellular housekeeping and metabolic functions through delivery of
cytoplasmic constituents for lysosomal degradation. In addition, it may mediate the …

Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is
crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self …