Background Pharmacotherapy provides an option for adults with overweight and obesity to
reduce their bodyweight if lifestyle modifications fail. We summarised the latest evidence for …

Objective To compare the benefits and harms of drug treatments for adults with type 2
diabetes, adding non-steroidal mineralocorticoid receptor antagonists (including finerenone) …

Background Whether video laryngoscopy as compared with direct laryngoscopy increases
the likelihood of successful tracheal intubation on the first attempt among critically ill adults is …

As of May 2022, there have been over 524 million confirmed cases of COVID-19 (10). The
pandemic has thus far claimed approximately 6.2 million lives (10). Vaccination is having a …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Importance Red blood cell transfusion is a common medical intervention with benefits and
harms. Objective To provide recommendations for use of red blood cell transfusion in adults …

The methods and results of systematic reviews should be reported in sufficient detail to allow
users to assess the trustworthiness and applicability of the review findings. The Preferred …

Background Whether proton-pump inhibitors are beneficial or harmful for stress ulcer
prophylaxis in critically ill patients undergoing invasive ventilation is unclear. Methods In this …

Background Interpretation of the evidence from randomised controlled trials (RCTs) of
remdesivir in patients treated in hospital for COVID-19 is conflicting. We aimed to assess the …

Preventive approaches have latterly gained traction for improving mental health in young
people. In this paper, we first appraise the conceptual foundations of preventive psychiatry …