Amplification-free electrochemical biosensor detection of circulating microRNA to identify drug-induced liver injury

A Roychoudhury, JW Dear… - Biosensors and …, 2023 - Elsevier
Drug-induced liver injury (DILI) is a major challenge in clinical medicine and drug
development. There is a need for rapid diagnostic tests, ideally at point-of-care. MicroRNA …

Cross-triggered and cascaded recycling amplification system for electrochemical detection of circulating microRNA in human serum

B Dou, H Zhou, Y Hong, L Zhao, P Wang - Chemical Communications, 2021 - pubs.rsc.org
A cross-triggered and cascaded recycling amplification system was developed for
electrochemical sensing of microRNA 122 based on the DNAzyme/multicomponent nucleic …

Highly sensitive detection of elevated exosomal miR-122 levels in radiation injury and hepatic inflammation using an aptamer-functionalized SERS-sandwich assay

M Muhammad, CS Shao, C Liu… - ACS Applied Bio …, 2021 - ACS Publications
Radiation-induced organ injury is one of the major fallouts noticed during radiotherapy
treatment of malignancies and other detrimental radiation exposures. MicroRNA (miRNA) …

A comprehensive review of Dynamic Chemical Labelling on Luminex xMAP technology: a journey towards Drug-Induced Liver Injury testing

A Marín-Romero, S Pernagallo - Analytical Methods, 2023 - pubs.rsc.org
Drug-Induced Liver Injury (DILI) is a grave global adverse event that can result in fatal
consequences, causing drug failures, market withdrawals, and regulatory warnings, leading …

An amplified logic gate driven by in situ synthesis of silver nanoclusters for identification of biomarkers

H Shen, Z Li, B Dou, Q Feng, P Wang - Chemical Communications, 2023 - pubs.rsc.org
An amplified DNA logic sensor was constructed for the identification of multiple biomarkers,
in which the inputs of targets triggered the disassembly of a V-shaped probe (VSP) structure …

[HTML][HTML] Recent advances in CRISPR/Cas systems-associated surface enhanced Raman spectroscopy biosensor towards nucleic acid detection

D Zhang, S He, Z Wang, P Yan, H Li, X Xu… - Medicine in Novel …, 2024 - Elsevier
Nucleic acids play a decisive role in vital life processes, such as growth, heredity, and
evolution, and exploring different types of nucleic acid detection techniques has always …

Open a new window in the world of circulating microRNAs by merging ChemiRNA Tech with a Luminex platform

A Marín-Romero, M Tabraue-Chávez, JW Dear… - Sensors & …, 2022 - pubs.rsc.org
microRNAs are small noncoding RNA molecules showing huge promise as biomarkers and
diagnostic tools for illnesses, as significant changes in their expression occur in response to …

High resolution biosensor to test the capping level and integrity of mRNAs

I Moya-Ramírez, C Bouton, C Kontoravdi… - Nucleic Acids …, 2020 - academic.oup.com
Abstract 5′ Cap structures are ubiquitous on eukaryotic mRNAs, essential for post-
transcriptional processing, translation initiation and stability. Here we describe a biosensor …

[HTML][HTML] SARS-CoV-2 viral RNA detection using the novel CoVradar device associated with the CoVreader smartphone app

C Martín-Sierra, MT Chavez, P Escobedo… - Biosensors and …, 2023 - Elsevier
The COVID-19 pandemic has highlighted the need for innovative approaches to its
diagnosis. Here we present CoVradar, a novel and simple colorimetric method that …

Cascaded recycling amplification mediated in situ synthesis of silver nanoclusters for the construction of sensitive and label-free electrochemical sensor

Z Li, K Wang, B Dou, Z Li, Y Qi, P Wang - Sensors and Actuators B …, 2024 - Elsevier
A growing number of studies have shown the crucial role of microRNA (miRNA) sensing in
cancer clinical diagnosis and prognosis research. In this study, a label-free and enzyme-free …