Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …

The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

Traumatic brain injury is a risk factor for subsequent neurodegenerative disease, including
chronic traumatic encephalopathy, a tauopathy mostly associated with repetitive concussion …

Aims: Using primary cultures of mouse hippocampal neurons, we studied the molecular and
functional interactions between high mobility group box-1 (HMGB1) and the N-methyl-d …

Voltage-gated calcium (Ca V) channels are associated with β and α 2 δ auxiliary subunits.
This review will concentrate on the function of the α 2 δ protein family, which has four …

Pregabalin is a specific ligand of the alpha 2-delta (α 2-δ) auxiliary subunit of voltage-gated
calcium channels. A growing body of evidence from studies of anxiety and pain indicate that …

Abstract α 2 δ proteins are membrane-anchored extracellular glycoproteins which are
abundantly expressed in the brain and the peripheral nervous system. They serve as …

In nerve cells the genes encoding for α2δ subunits of voltage-gated calcium channels have
been linked to synaptic functions and neurological disease. Here we show that α2δ subunits …

Prion diseases are fatal neurodegenerative diseases characterised by the accumulation of
misfolded prion protein (PrPSc) in the brain. They are caused by the templated misfolding of …