Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

The most widespread type of liver cancer, HCC, is associated with disabled cellular death
pathways. Despite therapeutic advancements, resistance to current systemic treatments …

The combination of immunotherapy and molecular targeted therapy exhibits promising
therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still …

The excessive inflammatory response of macrophages plays a vital role in the pathogenesis
of various diseases. The dynamic metabolic alterations in macrophages, including amino …

The advent of immunotherapy has significantly reshaped the landscape of cancer treatment,
greatly enhancing therapeutic outcomes for multiple types of cancer. However, only a small …

Low response rate and treatment resistance are frequent problems in the immunotherapy of
tumors, resulting in the unsatisfactory therapeutic effects. Ferroptosis is a form of cell death …

Background The outcome of hepatocellular carcinoma (HCC) is limited by its complex
molecular characteristics and changeable tumor microenvironment (TME). Here we focused …

The non-natriuretic-dependent glutamate/cystine inverse transporter-system Xc-is
composed of two protein subunits, SLC7A11 and SLC3A2, with SLC7A11 serving as the …

Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular
lipid peroxidation that plays a key role in the development of HCC. Studies have shown that …

Abstract Background Systemic sclerosis (SSc), with unclear pathophysiology, is a
paradigmatic rheumatic disease of immunity dysfunction-driven multi-organ inflammation …