CCAAT/enhancer binding protein (C/EBP) β and C/EBPδ are transcription factors of the
basic-leucine zipper class which share phylogenetic, structural and functional features. In …

Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the
pathogenesis of many inflammatory disorders, including those of the lung such as cystic …

Understanding the means by which microglia self-regulate the neuroinflammatory response
helps modulating their reaction during neurodegeneration. In amyotrophic lateral sclerosis …

Background Genetic aberrations in the NFκB pathway lead to primary immunodeficiencies
with various degrees of severity. We previously demonstrated that complete ablation of the …

Japanese encephalitis virus (JEV), a single‐stranded RNA (ssRNA) virus, is the leading
cause of encephalitis in Asia. Microglial activation is one of the key events in JEV‐induced …

Previous studies have indicated that EPO maintains the M2 microglia phenotype that
contributes to white matter repair after ischemic stroke in young mice (2 months old) …

Different levels of regulatory mechanisms, including posttranscriptional regulation, are
needed to elaborately regulate inflammatory responses to prevent harmful effects. Terminal …

Two vital functions of the innate immune system are to initiate inflammation and redistribute
micronutrients in favor of the host. Zinc is an essential micronutrient used in host defense …

TNFAIP3/A20 is a prominent autoimmune disease risk locus that is correlated with
hypomorphic TNFAIP3 expression and exhibits complex chromatin architecture with over 30 …

The human pathogen Helicobacter pylori infects more than half of the world's population and
is a paradigm for persistent yet asymptomatic infection but increases the risk for chronic …