Transcription of eukaryotic protein-coding genes commences with the assembly of a
conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general …

The transcription initiation factor TFIIH is a remarkable protein complex that has a
fundamental role in the transcription of protein-coding genes as well as during the DNA …

For the initiation of transcription, RNA polymerase II (Pol II) assembles with general
transcription factors on promoter DNA to form the pre-initiation complex (PIC). Here we …

In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that
assembles at the core promoter is required for the opening of the duplex DNA and …

Eukaryotic transcription initiation requires the assembly of general transcription factors into a
pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the …

DNA repair mechanisms are critical for maintaining the integrity of genomic DNA, and their
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …

Cellular information processing via reversible protein phosphorylation requires tight control
of the localization, activity, and substrate specificity of protein kinases, which to a large …

Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription
initiation by RNA polymerase II and nucleotide excision DNA repair. The TFIIH core complex …

The conserved Mediator co-activator complex has an essential role in the regulation of RNA
polymerase II transcription in all eukaryotes. Understanding the structure and interactions of …

Transcription factor IIH (TFIIH) is essential for both transcription and nucleotide excision
repair (NER). DNA lesions are initially detected by NER factors XPC and XPE or stalled RNA …