Molecular mechanisms and physiological importance of circadian rhythms
A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
Transcriptional architecture of the mammalian circadian clock
JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock
Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …
Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
Regulation and role of transcription factors in osteogenesis
WCW Chan, Z Tan, MKT To, D Chan - International journal of molecular …, 2021 - mdpi.com
Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …
Circadian clock genes and the transcriptional architecture of the clock mechanism
KH Cox, JS Takahashi - Journal of molecular endocrinology, 2019 - jme.bioscientifica.com
The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …
Interconnections between circadian clocks and metabolism
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …
environment; they are believed to be regulated by the core circadian clock interlocking …
Targeting glioblastoma stem cells through disruption of the circadian clock
Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells
(GSC). Here, we show that GSCs, differentiated glioblastoma cells (DGC), and nonmalignant …
(GSC). Here, we show that GSCs, differentiated glioblastoma cells (DGC), and nonmalignant …
Mutation of the human circadian clock gene CRY1 in familial delayed sleep phase disorder
A Patke, PJ Murphy, OE Onat, AC Krieger, T Özçelik… - Cell, 2017 - cell.com
Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes∼
24 hr rhythms in many behavioral and physiological processes. This system is altered in …
24 hr rhythms in many behavioral and physiological processes. This system is altered in …
Circadian clock regulation of hepatic lipid metabolism by modulation of m6A mRNA methylation
X Zhong, J Yu, K Frazier, X Weng, Y Li, CM Cham… - Cell reports, 2018 - cell.com
Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis,
disruptions of which can lead to metabolic diseases. Whether N 6-methyladenosine (m 6 A) …
disruptions of which can lead to metabolic diseases. Whether N 6-methyladenosine (m 6 A) …