Lipids are essential building blocks synthesized by complex molecular pathways and
deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Lysosomal acid lipase deficiency (LAL-D) is a rare autosomal recessive lysosomal storage
disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of …

Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-
density lipoprotein (LDL) cholesterol and premature cardiovascular disease, with a …

Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver injury, with a
worldwide prevalence that varies in proportion to those of obesity and diabetes mellitus …

The accumulation of damaged or excess proteins and organelles is a defining feature of
metabolic disease in nearly every tissue. Thus, a central challenge in maintaining metabolic …

Non-alcoholic fatty liver disease (NAFLD) is characterized by intra-hepatic fat accumulation
and mechanisms involved in its pathogenesis are not fully explained. Lysosomal Acid …

Non‐alcoholic fatty liver disease (NAFLD), an increasingly devastating human disorder, is
characterized by intrahepatic fat accumulation. Although important progress has been made …

Autophagy, or cellular self-digestion, is an orchestrated cellular pathway crucial for
development, differentiation, homeostasis, and survival of cells. The autophagic process is …

Lysosomes are a central organelle in the processing of exogenous and intracellular
biomolecules. Together with recent data that implicate the degradation products of …