Here, there, and everywhere: myeloid-derived suppressor cells in immunology

S Ostrand-Rosenberg, TJ Lamb… - The Journal of …, 2023 - journals.aai.org
Myeloid-derived suppressor cells (MDSCs) were initially identified in humans and mice with
cancer where they profoundly suppress T cell–and NK cell–mediated antitumor immunity …

Beyond immunosuppressive effects: dual roles of myeloid-derived suppressor cells in bone-related diseases

Z Ling, C Yang, J Tan, C Dou, Y Chen - Cellular and Molecular Life …, 2021 - Springer
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells (IMCs) with immunosuppressive functions, whereas IMCs originally …

Myeloid-derived suppressor cells prevent disruption of the gut barrier, preserve microbiota composition, and potentiate immunoregulatory pathways in a rat model of …

D Radojević, M Bekić, A Gruden-Movsesijan, N Ilić… - Gut …, 2022 - Taylor & Francis
Over-activated myeloid cells and disturbance in gut microbiota composition are critical
factors contributing to the pathogenesis of Multiple Sclerosis (MS). Myeloid-derived …

Aging affects the role of myeloid-derived suppressor cells in alloimmunity

A Schroeter, MJ Roesel, T Matsunaga, Y Xiao… - Frontiers in …, 2022 - frontiersin.org
Myeloid-derived suppressor cells (MDSC) are defined as a group of myeloid cells with
potent immunoregulatory functions that have been shown to be involved in a variety of …

[HTML][HTML] Recent advances in cell therapeutics for systemic autoimmune diseases

Y Park, SK Kwok - Immune Network, 2022 - ncbi.nlm.nih.gov
Systemic autoimmune diseases arise from loss of self-tolerance and immune homeostasis
between effector and regulator functions. There are many therapeutic modalities for …

Local and systemic injections of human cord blood myeloid-derived suppressor cells to prevent graft rejection in corneal transplantation

J Lee, HJ Sohn, CH Kim, TG Kim, HS Lee - Biomedicines, 2022 - mdpi.com
Myeloid-derived suppressor cells (MDSCs) are therapeutic agents to prevent graft rejection
in organ transplants by modulating inflammation. Herein, the immunosuppressive effect of …

The Function and Therapeutic Implications of TNF Signaling in MDSCs

K Yu, C Yu, L Jiao, K Miao, L Ni, X Rao, L Zhou, C Zhao - Biomolecules, 2022 - mdpi.com
Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous
myeloid cells with immunosuppressive functions. MDSCs play important roles in the …

[HTML][HTML] Engaging natural regulatory myeloid cells to restrict T-cell hyperactivation-induced liver inflammation via extracellular vesicle-mediated purine metabolism …

F Yang, R Men, L Lv, L Zhou, Q Deng, X Wang… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Dysregulated T-cell immune response-mediated inflammation plays critical roles
in the pathology of diverse liver diseases, but the underlying mechanism of liver immune …

[HTML][HTML] MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of ischemia/reperfusion injury after lung transplant

V Leroy, DJM Kollareth, Z Tu, JAC Valisno… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Lung transplantation (LTx) outcomes are impeded by ischemia/reperfusion injury (IRI) and
subsequent chronic lung allograft dysfunction (CLAD). We examined the undefined role of …

[HTML][HTML] Myeloid-derived suppressor cells ameliorate liver mitochondrial damage to protect against autoimmune hepatitis by releasing small extracellular vesicles

M Shen, X Fan, Y Shen, X Wang, R Wu, Y Wang… - International …, 2023 - Elsevier
Background Autoimmune hepatitis (AIH) is an inflammatory liver disease that is associated
with impaired self-tolerance. Myeloid-derived supprfessor cells (MDSCs) have been …